Acta Oto Laryngologica 2022-07-06

Cochlear implantation for post-meningitis deafness with cochlear ossification: diagnosis and surgical strategy

Na Zhang,Ruijuan Dong,Jun Zheng,Yanling Zhao,Yongxin Li,Xueqing Chen,Shouqin Zhao

Publication date 03-06-2022


Cochlear ossification (CO) after meningitis can cause profound sensorineural hearing loss (SNHL). Cochlear implantation (CI) is the ideal treatment strategy for CO. To explore the strategy for CI in patients with CO after meningitis. In this retrospective study, the medical records of patients diagnosed with profound SNHL due to CO after meningitis and who underwent CI in our department between September 2010 and September 2021 were collected and reviewed. Their imaging and surgical findings were analyzed. The data of 26 patients with unilateral CI were reviewed. All patients underwent preoperative temporal high-resolution computed tomography (HRCT) and 22 patients magnetic resonance imaging (MRI). The sensitivity of HRCT was 61.5% (10/26), whereas that of MRI was 81.8% (18/22). Combined HRCT and MRI achieved a detection rate of 92.3% (24/26). Twenty-two and four patients underwent complete and partial electrode implantations, respectively. Preoperative temporal bone HRCT and MRI are essential for determining whether a patient is suitable for CI and surgical planning. A false-negative diagnosis is possible when diagnosing CO, but combined HRCT and MRI can improve the positive rate of preoperative diagnosis of CO post meningitis. Early CI is recommended.

Pubmed PDF Web

Endoscopic type 1 tympanoplasty: comparison of the effects of three different thicknesses grafts

Qinshuang Zhou,Lanlan Jin,Xiaoxiao Song,Haifeng Zheng,Yideng Huang

Publication date 14-05-2022


The effects of graft thickness on tympanoplasty is uncertain. To compare the results of endoscopic tympanoplasty using different thicknesses of autologous tissues. This retrospective analysis included 186 patients who received type I tympanoplasty, divided into three main groups based of grafting material: perichondrium (A), cartilage-perichondrium (B), or cartilage-perichondrium plus additional perichondrium (C). Group A was subdivided based on whether the placement was inside (A1) or outside (A2) of the malleus. The hearing improvement, graft success rate, and surgery duration were analysed. Statistical analysis showed significant hearing improvement in the three main groups ( Our results suggest that graft thickness affects hearing recovery; however, graft thickness does not affect the rate of grafting success. Endoscopic transplantation of the perichondrium is more difficult and requires more time.

Pubmed PDF Web

The clinical outcome of the patients with horizontal semicircular canal variants of benign paroxysmal positional vertigo

Yasuo Ogawa,Taro Inagaki,Takahito Kondo,Atsuo Takeda,Noriko Nagai,Shigeto Itani,Koji Otsuka

Publication date 03-05-2022


Gufoni maneuver is known to be effective for horizontal canal benign positional vertigo (HC-BPPV), but there are some intractable patients that the treatment procedure does not work. The clinical outcomes of patients with HC-BPPV were investigated. We also investigated the characteristics of intractable patients which needed long time to the remission. Sixty-six patients with HC-BPPV receiving Gufoni maneuver at Tokyo Medical University Hachioji Medical Center were investigated. The patients were classified into geotropic DCPN group and apogeotropic DCPN group. The clinical outcomes in 2 groups were examined. There were 48 patients with geotropic DCPN and 18 patients with apogeotropic DCPN. There were significant differences between the geotropic HC-BPPV and apogeotropic HC BPPV in the period to remission. There were 7 intractable patients and the average ages of these intractable patients were higher than other patients. The patients with geotropic DCPN and the patients with the nystagmus conversion from apogeotropic to geotropic DCPN have tendency to easy to resolve, but in patients with apogeotropic type without nystagmus transformation have long time to resolve. The elderly patients whose nystagmus remains apogeotropic without nystagmus conversion have tendencies to become intractable.

Pubmed PDF Web

Efficiency of a novel middle ear pressure device for intractable definite Meniere’s disease and delayed endolymphatic hydrops after certification by the public health insurance system in Japan

Akira Nakazato,Hiromasa Takakura,Tram Anh Do,Naoko Ueda,Noriaki Takeda,Yukio Watanabe,Hideo Shojaku

Publication date 12-05-2022


Middle ear pressure therapy (MEPT) is effective in treating intractable vertigo in patients with definite Meniere's disease (MD) and delayed endolymphatic hydrops (DEH) refractory to conservative treatment. A novel middle ear pressure device, the EFET01 To examine short-term therapeutic effect of MEPT using the ETET01 Patients selected according to Japan Society for Equilibrium Research (JSER) guidelines underwent MEPT using the EFET01 from September 2018 to July 2021, and 44 patients were enrolled in this retrospective study. Clinical data analysed at 4 months after the start of MEPT were compared with those of the previous clinical trial for the EFET01. MEPT using the EFET01 showed the same therapeutic efficacy as that of the previous clinical trial, i.e. improvement in the intensity and frequency of vertigo with no effect on hearing, even under JSER guidelines for proper use of MEPT. MEPT using the EFET01 provided an effective treatment option for intractable vertigo in patients with definite MD and DEH.

Pubmed PDF Web

Fluorescence in situ hybridization and microbial community profiling analysis of explanted cochlear implants

Leena Asfour,Daniel Smyth,Cynthia B. Whitchurch,Rosalia Cavaliere,J. Thomas Roland

Publication date 14-05-2022


Cochlear implant (CI) infections affect a small, but significant number of patients. Unremitting infections can lead to explantation. Fluorescence To describe the results and clinical significance of bacterial analyses conducted on explanted CIs. Between 2013 and 2017, 12 explanted devices underwent microbiological analysis in addition to the manufacturer's device failure analysis. Patients' clinical history, infection status and outcome were reviewed and correlated with microbial analysis results. From 2013 to 2017, 12 Cochlear™ devices from 11 patients underwent additional MCP or FISH analysis. Five devices were explanted due to suspected implant associated infection, and seven were explanted for other reasons. FISH analysis revealed biofilm presence on all infected devices, only partial correlation of cultures with biofilm composition and confirmation that biofilm formation occurs preferentially at particular device interfaces and geometries. MCP analysis presented challenges in data analysis inherent to its technique but correlated with cultures of infected devices and suggested a diverse microbial composition of explanted devices. Microbial analysis of explanted devices can aid in further elucidating treatment approaches to infected CIs.

Pubmed PDF Web

Efficacy of steroid treatment for sudden sensorineural hearing loss in patients with vestibular schwannoma

Se A Lee,Shin Young Kim,Youngjeong Lee,Jong Dae Lee

Publication date 28-05-2022


Sudden sensorineural hearing loss (SSNHL) has several aetiologies and may be a presenting symptom of vestibular schwannoma (VS). The aim of this study was to investigate the recovery rate after steroid treatment and the prognostic factors of SSNHL with VS. This was a retrospective observational study wherein 32 patients with VS who presented with SSNHL were analysed at a tertiary referral centre. Hearing gain and prognostic factors were the main outcome measures for steroid treatment intervention. Among the 1698 patients presenting with SSNHL, VS was found in 43 (2.5%) patients. Eleven cases (34.3%) showed good recovery, with significant improvements in the pure-tone audiometry values. Even though age was a significant factor, there were no associations between steroid response and initial hearing level, presence of vertigo, tumour size, and tumour extension. Our study showed that hearing recovery of SSNHL does not exclude a VS diagnosis. We suggest that steroid treatment be considered in patients with VS presenting SSNHL.

Pubmed PDF Web

Endolymphatic hydrops presumption tests for patients with vestibular migraine

Toru Seo,Yohei Okano,Mizuho Aomi,Zenyu Yamada,Shigeru Kasugai,Manabu Nakamura,Yasuhiro Miyamoto,Izumi Koizuka

Publication date 02-06-2022


The aetiology of vestibular migraine (VM) has not yet been defined; endolymphatic hydrops (EH) has been suggested as a candidate. This study aimed to clarify the relationship between VM and EH using neuro-otological tests, including the EH presumption test. Fourteen patients with VM underwent caloric testing, video head impulse test (vHIT), cervical and ocular vestibular evoked myogenic potential (cVEMP and oVEMP), and EH presumption tests such as the Futaki's test and furosemide loading VEMP. Caloric testing was abnormal in two of the 14 cases (14.3%), and vHIT was abnormal in one of 12 cases (8.3%). Abnormal asymmetry ratios (ARs) of cVEMP and oVEMP were observed in two of 14 cases (14.3%) and six of 13 cases (46.2%), respectively. Futaki's test results were positive in five of 14 cases (35.7%). Furosemide loading VEMP was positive in seven of 14 cases (50.0%). Nine patients (64.3%) were positive for at least one EH presumption test. EH is not a rare finding in VM; however, the ratio is less than that in Meniere's disease.

Pubmed PDF Web

Prevalence of severe-to-Profound hearing loss in the adult Swedish population and comparison with cochlear implantation rate

Christian Löfvenberg,Per-Inge Carlsson,Marie Louise Barrenäs,Åsa Skagerstrand,David Simic,Jonas Carlsson,Jessica Wigdén,Eva Westman

Publication date 01-06-2022


The prevalence of disabling hearing loss is increasing worldwide. However, previous studies on hearing loss prevalence have enrolled small populations or only provided estimates. To establish the prevalence of severe-to-profound hearing loss (STPHL) in the adult Swedish population and compare it with the cochlear implantation rate in Sweden. We established a database containing over 15 million audiograms obtained from regions covering > 99% of the Swedish population by extracting audiogram data from the computer software application, Auditbase. We used this database to calculate the percentage of adult patients with bilateral hearing levels ≥ 70 dB. We collected data regarding cochlear implantations in Sweden from the National Board of Welfare and Health. The prevalence of STPHL in the adult Swedish population was 0.28%. There were regional variations in the prevalence and rate of cochlear implantation; however, there was no association between both parameters. This study presents an updated and reliable prevalence figure for STPHL in Sweden. Patients with STPHL have extensive rehabilitation requirements; accordingly, it is important to determine the accurate prevalence of STPHL to inform the allocation of adequate resources.

Pubmed PDF Web

Acoustic neuromas associated with sudden sensorineural hearing loss

Mariko Takahashi,Akira Inagaki,Noritaka Aihara,Shingo Murakami

Publication date 03-06-2022


Several studies have reported sudden sensorineural hearing loss (SHL) as an initial symptom of acoustic neuromas (ANs). We aimed to retrospectively evaluate the incidence of SHL and the associated rates of post-treatment improvement in patients diagnosed with ANs. We analysed the clinical data of 686 patients with ANs and examined tumour size, correlation with hearing loss, number of episodes of SHL, extent of auditory recovery, and associated audiogram patterns. Among 686 enrolled patients with ANs, 232 (86 with intracanalicular and 146 with extrameatal tumours) experienced SHL at some point in their clinical history. The incidence of SHL was not significantly associated with tumour size. Of the 172 patients analysed, 119, 44, and 9 patients experienced one, two, or three or more episodes of SHL, respectively. Confirmed auditory recovery occurred in 61%, 45.3%, and 33.3% of the patients after the first, second, or third or later episodes of SHL, respectively. The audiograms of 78/172 (45.3%) patients showed a typical trough-shaped pattern of hearing loss at medium-level frequencies. Among patients with ANs, 7.7% experienced two or more episodes of SHL. The recovery rate of SHL decreased with each successive occurrence.

Pubmed PDF Web

Carotid interposition in patients with head and neck tumors: clinical experience of 13 cases reconstructed with a great saphenous vein autograft

Sherif Abolfotouh,Leif Bäck,Katri Aro,Patrik Lassus,Jyrki Vuola,Karri Mesimäki,Tommy Wilkman,Pirkka Vikatmaa

Publication date 03-05-2022


Carotid interposition graft (CIG) surgery in the setting of head & neck cancer (HNC) is a rare procedure with a limited number of cases described in the literature. To assess the outcomes of the surgery at Helsinki University Hospital. Patients who underwent CIG in a head and neck tumor surgery were retrospectively analyzed over 15 years. Overall-survival (OS) was calculated until 1 May 2020. The primary-outcome was to measure the 30-day OS, postoperative stroke rate, and other complications. The secondary-outcome was to measure 1-, 2-, and 5-year OS. Thirteen patients were identified, 11 with HNC and two with Shamblin III Carotid Body Tumors. The great saphenous vein was used for all vascular reconstructions, and shunting was routinely performed. The 30-day stroke incidence was nil. Two graft-blowouts were encountered, one of which lead to death and the other was successfully managed. For HNC patients, the locoregional recurrence-rate was 36%. The 5-year OS was 46.2%. CIG in HNC setting can achieve oncologic-control with an acceptable rate of complications. Routine shunting, heparinization, and elevating blood-pressure during closure seem to be safe protocols to maintain cerebral-circulation perioperatively. A moderate graft-blowout risk should be considered.

Pubmed PDF Web

Covid-19 outbreak: does the use of a surgical mask impact the sense of smell?

Clémentine Hyvrard,Margaux Petitjean,Maxime Fieux,Françoise Zerah,André Coste,Sophie Bartier

Publication date 18-05-2022


The current context of Covid-19 pandemic has broadened mask use. Evaluate the impact of wearing a surgical mask on sense of smell by comparing the results of sniffin' sticks test (SST) with and without a surgical mask and evaluate the feasibility of practicing SST with a mask. A crossover prospective comparative study between two groups of volunteers.
The results of SST with a mask were compared to the results without a mask: group 1 first performed SST with a surgical mask and then one week later performed SST without a mask, while group 2 started without a mask. Twenty volunteers were included. In group 1 and 2, all the subjects, except one, had a significantly better total score (TDI) without a mask. The average TDI difference score with and without a mask, was inferior to 5. 8/20 (40%) subjects had a TDI difference superior to 5 with and without mask, while 4/20 (20%) were normosmic without a mask, while being recategorized as hyposmic with a mask. Wearing a surgical mask may reduce the sense of smell, in a cohort of normosmic patients. Further larger studies must be conducted in hyposmic subjects.

Pubmed PDF Web

Long-term efficacy of turbinoplasty compared with medical treatment in patients with allergic rhinitis

Shin Hyuk Yoo,Ji Hyeok Choi,Ji-Hun Mo

Publication date 01-06-2022


The effectiveness of turbinate surgery has been proven in patients with allergic rhinitis (AR). This study evaluated the long-term efficacy of turbinoplasty in AR and to compare the results with those of medical treatment. This study included 192 patients diagnosed with AR who underwent surgical or medical treatment. Medical records were reviewed to assess pre-treatment and 2-year post-treatment frequency and severity of AR symptoms, prescription frequency for AR medication, and satisfaction score for treatment. Parameters for 5-year post-treatment efficacy were acquired Patients in the turbinoplasty group demonstrated significant improvements in all allergic symptom scores, while those in the medication group showed significant symptom improvement only in nasal obstruction on long-term follow-up. Patients in the turbinoplasty group also showed a lower prescription frequency after treatment and higher subjective satisfaction scores than those in the medication group. This long-term follow-up study demonstrated that turbinoplasty for AR appears to be an effective treatment option compared with medical therapy alone.

Pubmed PDF Web

The effect of laryngopharyngeal reflux on arousal in patients with obstructive sleep apnea

Peipei Ji,Lei Shi,Dengxiang Xing,Jie Qin,Chenhai Zheng,Shuhua Li,Dahai Wu

Publication date 28-05-2022


Laryngopharyngeal reflux (LPR) may be associated with the severity of obstructive sleep apnea (OSA). However, it is unknown whether LPR may be associated with arousal. To clarify the effect of LPR on arousal in OSA. This study included 120 OSA patients. The correlations between LPR scores and arousal index (ArI) were analyzed. Finally, to further clarify the effect of LPR on ArI, we analyzed the correlations between respiratory event-related arousal index (BERAI), leg-movement-related arousal index (LMRAI), snore-related arousal index (SRAI), spontaneous arousal index (SAI), and RSI score. Partial correlation analysis showed that the RSI score was positively correlated with ArI ( The effect of LPR symptoms on arousal in OSA exists. The more severe the LPR was, the more frequent the arousal in OSA patients was. Thereinto, respiratory event-related arousal and spontaneous arousal were the most obvious.

Pubmed PDF Web

Clinical effect of CO2 laser resection of the epiglottic cyst under micro-laryngoscope suspension

Dengsheng Chen,Maoli Duan

Publication date 03-06-2022


Epiglottic cysts are common diseases and have multiple morbidity, and traditional surgery causes intraoperative bleeding and postoperative recurrence. To investigate the therapeutic effect of CO Eighty patients with epiglottic cysts were randomly enrolled into the CO The CO The CO

Pubmed PDF Web

Identification of a novel DFNA5 mutation, IVS7-2 a\u2009>\u2009G, in a Chinese family with non-syndromic sensorineural hearing loss

ZhanGuo Jin,Qingwen Zhu,Yu Lu,Jing Cheng,HuiJun Yuan,DongYi Han

Publication date 01-06-2022


To date, seven In this study, we found an autosomal-dominant non-syndromic hearing loss Chinese pedigree which spanned four generations and comprised 43 members. We want to identify the causative gene and mutation. Application of microsatellite markers on DFNA 23 loci preliminary screening of 25 genes, data were analyzed by linkage analysis. We mapped the locus to the region between D7S629 and D7S516 (two-point lod-score of 5.39) with the application of 8 microsatellite markers. By direct sequencing of candidate genes in mapping region, we identified a novel missense mutation ivs7-2 A > G in DFNA5 gene, which was faithfully cosegregated with hearing loss in the family. The missense mutation in intron 7 of

Pubmed PDF Web

Autoinflation compared to ventilation tubes for treating chronic otitis media with effusion

Armin B. Moniri,João Lino,Luaay Aziz,Richard M. Rosenfeld

Publication date 06-07-2022


Otitis media with effusion (OME) is the most common cause of acquired hearing loss and surgery in children. Autoinflation has been suggested as an alternative treatment for OME. The aim of the study was to compare treatment outcome with a new autoinflation device versus ventilation tube (VT) surgery or watchful waiting in children with chronic bilateral OME from the waiting list for surgery. Forty-five children performed autoinflation during four weeks, forty-five were submitted to VT surgery, and twenty-three were enrolled as control group. Tympanometry was performed in the autoinflation and the control groups and audiometry in all groups. An equivalent hearing improvement was achieved in the autoinflation and the VT group at one ( Autoinflation achieved an equivalent improvement in hearing thresholds compared to VT surgery for treating OME. Autoinflation may be a reasonable first-line treatment for children with OME to potentially avoid surgery.

Pubmed PDF Web

Identifying chronic rhinosinusitis without nasal polyps by analyzing aspirated nasal air with an electronic nose based on differential mobility spectrometry

Jussi Virtanen,Anton Kontunen,Jura Numminen,Niku Oksala,Markus Rautiainen,Antti Roine,Ilkka Kivekäs

Publication date 06-07-2022


The diagnosis of chronic rhinosinusitis (CRS) is a complicated procedure. An electronic nose (e Nose) is a novel method that detects disease from gas-phase mixtures, such as human breath. To determine whether an e Nose based on differential mobility spectrometry (DMS) can detect chronic rhinosinusitis without nasal polyps (CRSsNP) by analyzing aspirated nasal air. Adult patients with CRSsNP were examined. The control group consisted of patients with septal deviation. Nasal air was aspirated into a collection bag and analyzed with DMS. The DMS data were classified using regularized linear discriminant analysis (LDA) models with 10-fold cross-validation. The accuracy of the DMS to distinguish CRSsNP from patients with septal deviation was 69%. Sensitivity and specificity were 67 and 70%, respectively. Bonferroni-corrected statistical differences were clearly noted. When a subgroup with more severe inflammatory disease was compared to controls, the classification accuracy increased to 82%. The results of this feasibility study demonstrate that CRSsNP can potentially be differentiated distinguished from patients with similar nasal symptoms by analyzing the aspirated nasal air using DMS. Further research is warranted to evaluate the ability of this novel method in the differential diagnostics of CRS.

Pubmed PDF Web

Proposal of a magnetic resonance imaging follow-up protocol after cholesteatoma surgery: a prospective study

Edoardo Covelli,Valerio Margani,Chiara Filippi,Haitham H. Elfarargy,Luigi Volpini,Andrea Romano,Alessandro Bozzao,Maurizio Barbara

Publication date 06-07-2022


Non-echo planar (EPI) diffusion-weighted (DW) MRI has become an effective tool for the follow-up after cholesteatoma surgery and decreased the rate of second-look surgeries. To shed light on the optimal imaging follow-up protocol to detect postoperative residual or recurrent cholesteatoma. 64 patients were included in this prospective study.
Three different surgical procedures were considered: canal-wall-up (26 patients), canal-wall-down (20 patients), and obliterative (18 patients). The imaging follow-up protocol included non-EPI DW MRI during the following postoperative periods: 1 month, 6 months, and 1, 3, 5, and 7 years after the primary surgery. MRI-positive lesions were present in 18.75% of patients. 50% of the MRI-positive findings occurred at the 1-month follow-up. The other peak of MRI positivity occurred at the 3-year follow-up. The last MRI-positive finding appeared at the 5-year follow-up. The timing for the imaging protocol proposed by this prospective study to detect recidivism after cholesteatoma surgery stressed the importance of performing non-EPI DW MRI for detecting residual, though rare, disease. Likewise, extending the follow-up to a least 5 years after primary surgery was also recommended to detect any recurrent cholesteatoma that would appear unlikely to be present beyond this time set.

Pubmed PDF Web

Evaluation of effect of septoplasty on nasal mucosal dryness using intranasal Schirmer test

Kubra Topal,Ayhan Kars,Fatma Atalay,Korhan Kılıc

Publication date 25-06-2022


Septal deviation causes the air entering the nose to encounter resistance and leads to turbulent flow formation by disrupting laminar air flow. In the literature, the Schirmer test has been recommended to evaluate the moistening of the nasal mucosa. The purpose of this study was to evaluate the degree of nasal humidification using the intranasal schirmer test in patients with septal deviation and to reveal changes in mucosal dryness and humidity in both nasal cavities following septoplasty surgery. Fifty-three patients with septal deviation detected at endoscopic rhinoscopic examination and scheduled for surgery were enrolled. Schirmer test was performed twice, at a one-month interval, pre- and postoperatively and test records were compared. The Schirmer test value for the deviated side of the septum was significantly lower than that for the contralateral side, for both nasal cavities. Schirmer test values increased significantly on the side of the septal deviation compared to the preoperative values. Septoplasty surgery performed for septal deviation significantly and reduces nasal mucosa dryness so increases Schirmer test results on the deviated side. We attribute this to septal deviation impairing air flow in the nasal cavity and causing nasal mucosa dryness.

Pubmed PDF Web

Total auricular reconstruction concomitant with BONEBRIDGE implantation using a retrosigmoid sinus approach

Danni Wang,Bingqing Wang,Ran Ren,Yue Wang,Jinsong Yang,Peiwei Chen,Shouqin Zhao,Qingguo Zhang

Publication date 24-06-2022


Retrosigmoid sinus (RS) approach was not the dominant choice for BONEBRIDGE implantation. To investigate the efficacy and safety of auricular reconstruction concomitant with BONEBRIDGE implantation using retrosigmoid approach for aural atresia patients. A retrospective analysis was conducted of 15 children (28 ears) who underwent auricular reconstruction using a completely expanded postauricular flap with a skin expander concomitant with retrosigmoid BONEBRIDGE implantation from July 2019 to September 2020. All 15 patients healed well and had no bone conduction shift. Average SFT improvement was 27.1 dB HL ( For patients who undergo auricle reconstruction using expanded postauricular flap, retrosigmoid approach can avoid interfering the flap of reconstructed auricular without increasing the surgical risk or impact the clinical efficacy, and without significantly prolonging the total anesthesia time. The integrated surgical approach is a safe, and convenient option for patients who require simultaneous auricular reconstruction with BONEBRIDGE implantation.

Pubmed PDF Web

miR-34a predicts the prognosis of advanced-stage external auditory canal squamous cell carcinoma

Naotaro Akiyama,Tomomi Yamamoto-Fukuda,Hiromi Kojima

Publication date 23-06-2022


External auditory canal (EAC) squamous cell carcinoma (SCC) is a rare disease, and the survival rate is low in the advanced stages. It has been reported that miR-34a expression is low in many cancers and acts as a tumor suppressor, but its function in EACSCC has not yet been reported. To analyze the miR-34a expression levels in EACSCC specimens using We performed microRNA ISH for miR-34a detection and immunohistochemical analysis of p53 and Ki67 in the EACSCC and otitis externa (OE) specimens. miR-34a was expressed in the basal and suprabasal layers in the OE epidermis. The pronounced expression of miR-34a was observed in the two cases of T2 (Stage II). In the one case of T3 (Stage III), it was almost the same as that of the OE. On the other hand, the expression levels of miR-34a in the one case of T3 (Stage IV) and two cases of T4 (Stage IV) were apparently reduced. We demonstrated that the expression level of miR-34a was higher in early-stage EACSCC and lower in advanced-stage EACSCC. The expression level of miR-34a may predict a prognosis in patients with advanced-stage EACSCC.

Pubmed PDF Web

The advantages of vestibular-evoked myogenic potentials induced by bone-conducted vibration in patients with otitis media

Ying Cheng,Qing Zhang,Yuzhong Zhang,Zichen Chen,Weijun Ma,Min Xu

Publication date 23-06-2022


At present, there is no consensus on the optimal methods for the diagnosis of vestibular dysfunction. To explore the advantages of bone-conducted vibration (BCV) related vestibular-evoked myogenic potentials (VEMPs). Fifty patients with otitis media volunteered for VEMP examination. They were randomly selected with air-conducted sound and BCV stimulation VEMPs assessed in both ears. The provocation rate of BCV-VEMPs was significantly higher than that of air-conducted sound VEMPs. Among 50 affected ears, there was no significant difference in the provocation rate of BCV-VEMPs between patients with air-bone conduction gaps lower or higher than 20 dB. There was no significant difference in the provocation rate of BCV-VEMPs between both ears in 30 patients with unilateral otitis media and the comparison of BCV-oVEMP parameters made no significant difference in amplitude, N1 latency, P1 latency, or N1-P1 duration, except for the threshold. A comparison of BCV-cVEMP parameters between affected and healthy ears revealed no significant difference between groups in terms of threshold, amplitude, N1 latency, P1 latency, or n1-p1 duration. BCV-VEMPs may be stably induced in patients with conductive hearing loss.

Pubmed PDF Web

Evaluation of age-related changes in middle-ear structures by wideband tympanometry

Doğukan Özdemir,Dursun Mehmet Mehel,Ayşe Bel Çeçen,Şule Özdemir,Ömer Küçüköner,Abdulkadir Özgür

Publication date 23-06-2022


Presbycusis is bilateral sensorineural hearing loss associated with the progressive degeneration of cochlear and central auditory pathways with aging. We aimed to reveal age-related changes in middle ear function by using wideband tympanometry (WBT). Fifty-eight patients diagnosed with presbycusis were compared to 52 audiologically healthy participants. WBT measurement was performed on both ears There were no statistically significant differences detected among the resonance frequencies or maximum absorbance ratios measured in both ears between groups ( The significant differences detected in compliance and absorbance values for high frequencies in presbycusis patients were remarkable. Thus, it has been shown that WBT yields an advantage compared to traditional tympanometry in the diagnosis and treatment of middle ear diseases.

Pubmed PDF Web

Inner ear impairment after stapedotomy: do the cervical vestibular evoked myogenic potentials play a diagnostic role?

Valerio Margani,Rita Talamonti,Anna Teresa Benincasa,Alessia Gorla,Edoardo Covelli,Haitham H. Elfarargy,Maurizio Barbara

Publication date 23-06-2022


Otosclerosis is characterized by a bony remodeling process that ends up with stapes fixation. The hearing impairment can be recovered by surgery by replacing the stapes superstructure. Due to the surgical management of the vestibule, the vestibular examination could provide an insight into the correlation between this kind of surgery and vestibular changes. To evaluate the impact of the stapedotomy on the inner ear. We evaluated pure tone audiometry and the presence of vestibular evoked myogenic potentials (VEMPs) in 41 patients with otosclerosis before and after the stapedotomy operation. Air conduction (Ac)-VEMPs were present in 18 cases preoperatively and 31 cases postoperatively. Bone conduction (Bc)-VEMPs were present in 23 cases preoperatively and 33 cases postoperatively. ABG was closed to less than 20 dB in all cases after the operation. The preoperative Bc-VEMPS had an outstanding capability to predict the type of hearing loss. The postoperative absence of VEMPS despite the closure of ABG indicated the impact of otosclerosis on the saccular cells. The use of Thulium Laser in stapedotomy didn't affect significantly the saccular cells. Integrated use of audiometry and VEMPs was effective to evaluate the changes associated with otosclerosis and the stapedotomy operation.

Pubmed PDF Web

12-month effect of middle ear pressure therapy with the EFET01 device for intractable definite Meniere’s disease and delayed endolymphatic hydrops after certification by the public health insurance system in Japan

Akira Nakazato,Hiromasa Takakura,Naoko Ueda,Tram Anh Do,Noriaki Takeda,Yukio Watanabe,Hideo Shojaku

Publication date 21-06-2022


Middle ear pressure therapy (MEPT) is effective for intractable vertigo in patients with definite Meniere's disease (MD) and treatment-refractory delayed endolymphatic hydrops (DEH). Four-month MEPT with the EFET01 Examine the therapeutic effect of 12-month MEPT using the ETET01 Patients underwent MEPT using the EFET01 MEPT with the EFET01 MEPT with the EFET01 The efficacy of 12-month MEPT with the EFET01

Pubmed PDF Web

Olfactory function trends in COVID-19 patients: a prospective cohort study

Maryam Akbari,Mir Mohammad Jalali,Maliheh Akbarpour,Ali Alavi Foumani,Saeede Sharifnia

Publication date 21-06-2022


One of the most common symptoms in COVID-19 patients is olfactory and taste dysfunction. This study aimed to evaluate the olfactory threshold, and identification using objective tests in the Iranian population. The present study was a prospective cohort study conducted in 2020-2021 on clinically recovering COVID-19 patients. Olfactory function was evaluated at the baseline, 4-6 weeks, and 12 weeks later. Olfactory threshold assessment was performed using the Saba Sabalan kit. The Iranian version of the Pennsylvania Smell Identification Test (IR-SIT) was used for olfactory identification. The olfactory threshold was categorized as poor (<8) and good olfaction (≥8). In the present study, 111 patients were examined, including 55 men and 56 women (mean age 41.4 and 53.4 years, respectively). The mean olfactory threshold was better for men (7.2) than for women (6.6). Analysis showed age to have a negative relationship with good olfaction at baseline (OR = 0.93, Objective tests are appropriate methods for assessing olfactory dysfunction in COVID-19 patients. Further studies are recommended.

Pubmed PDF Web

Concentration of hypoxia-inducible factor-1, glucose transporter 1 and vascular endothelial growth factor in tissue samples and serum in patients with primary laryngeal carcinoma

Izabela Bronikowska,Elzbieta Swietochowska,Robert Morawski,Pawel Sowa,Eugeniusz Czecior

Publication date 21-06-2022


Markers of tumorigenesis are essential factors which may play a major role in the early detection of head and neck carcinoma. To assess concentration of HIF-1, GLUT1 and VEGF in tissue samples and blood serum and its correlation to the tumour size, nodal disease, pathologic differentiation and patients' data. Fifty-two patients diagnosed with laryngeal carcinoma stage I-IV in which concentration of HIF-1, GLUT1 and VEGF was assessed in tissue samples and blood serum using immunoassay method. HIF-1α, GLUT1, VEGF concentration was significantly higher in cancer tissue samples than in normal tissue ( The results show that high concentration of HIF-1α, GLUT1 and VEGF might be suggestive of carcinogenic process when diagnosing patients with laryngeal lesions and could promote early detection of malignancy. The results of this study show importance of biochemical assessment in malignant tumours which may affect clinical decisions.

Pubmed PDF Web

Morphology changes in the cochlea of impulse noise-induced hidden hearing loss

Guowei Qi,Lei Shi,Handai Qin,Qingqing Jiang,Weiwei Guo,Ning Yu,Dongyi Han,Shiming Yang

Publication date 21-06-2022


This study was focused on impulse noise induces hidden hearing loss. This study was designed to determine the morphology changes of noise-induced hidden hearing loss (NIHHL).
Fifteen guinea pigs were divided into three groups: noise-induced hidden hearing loss (NIHHL) group, noise-induced hearing loss (NIHL) group, and normal control group. For the NIHHL group, guinea pigs were exposed to 15 times of impulse noise with peak intensity of 163 dB SPL at one time. For the NIHL group, animals were exposed to two rounds of 100 times impulse noise, and the time interval is 24 h. Auditory brain response (ABR) was tested before, immediately, 24 h, one week, and one month after noise exposure to evaluate cochlear physiology changes. One month after noise exposure, all guinea pigs in three groups were sacrificed, and basement membranes were carefully dissected immediately after ABR tests. The cochlea samples were observed by transmission electron microscopy (TEM) to find out the morphology changes. The ABR results showed that 15 times of impulse noise exposure could cause NIHHL in guinea pigs and 200 times could cause completely hearing loss. Impulse noise exposure could cause a dramatic increase of mitochondria in the inner hair cell. The structures of ribbon synapse and heminode were also obviously impaired compared to the normal group. The nerve fiber and myelin sheath remained intact after impulse noise exposure. This research revealed that impulse noise could cause hidden hearing loss, and the changes in inner hair cells, ribbon synapse, and heminode all played a vital role in the pathogenesis of hidden hearing loss.

Pubmed PDF Web

Copyright © KNO-T, 2020 | R/Abma