Acta Oto Laryngologica 2020-09-12

Dexamethasone delivery for hearing preservation in animal cochlear implant model: continuity, long-term release, and fast release rate

Min Young Lee,Young Cheol Kim,Jongmoon Jang,Jae Yun Jung,Hongsoo Choi,Jeong Hun Jang,Yun-Hoon Choung

Publicatie 26-05-2020


Clinically, steroids have been used for hearing preservation both topically and systemically during cochlear implantation.

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Comparison of furosemide-loading cervical vestibular-evoked myogenic potentials with magnetic resonance imaging for the evaluation of endolymphatic hydrops

Ko Shiraishi,Noriko Ohira,Takaaki Kobayashi,Mitsuo Sato,Yasuhiro Osaki,Katsumi Doi

Publicatie 24-07-2020


Furosemide-loading cervical vestibular-evoked myogenic potential (FVEMP), in which vestibular function is improved Twenty patients with definite unilateral Menière's disease were included. All subjects underwent both, FVEMP and inner ear MRI examinations. The results were then compared statistically between the affected and contralateral ears and among the methods. FVEMP and inner ear MRI of the cochlea, saccules, and utricles yielded positive results indicative of endolymphatic hydrops in 55.0%, 60.0%, 45.0%, and 45.0% of cases, respectively. The results of FVEMP were more consistent with those of the cochlea ( FVEMP appears to be a good and minimally invasive option for evaluating endolymphatic hydrops. However, the combination of FVEMP and inner ear MRI may yield even more accurate evaluations of endolymphatic hydrops.

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Comparison of the video head impulse test results with caloric test in patients with Meniere’s disease and other vestibular disorders

Masayuki Shugyo,Taeko Ito,Tomoyuki Shiozaki,Daisuke Nishikawa,Hiroki Ohyama,Hiroto Fujita,Toshiaki Yamanaka,Tadashi Kitahara

Publicatie 22-05-2020


The caloric test has been used to evaluate the semi-circular canal function for decades. In 2009, the video head impulse test (vHIT) was introduced, which can be used to evaluate the semi-circular canal function within a short time. Although both tests examine the semi-circular canal, the stimulation methods differ and it is unclear whether the vHIT is equivocal to the caloric test.

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Clinical features of 22q11.2 deletion syndrome related to hearing and communication

Noriomi Suzuki,Sho Kanzaki,Takafumi Suzuki,Kaoru Ogawa,Hiroyuki Yamagishi

Publicatie 05-06-2020


Individuals with 22q11.2 deletion syndrome (22q11.2DS) exhibit various phenotypes.

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Vestibular migraine and benign paroxysmal positional vertigo, close presentation dilemma

Mahmoud M. Mahrous

Publicatie 20-06-2020


Not only an association between benign paroxysmal positional vertigo (BPPV) and migraine have been recognized in the literature, but also, there are close similarities between BPPV and vestibular migraine (VM) presentations as both can be presented by very similar positional nystagmus.

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Microdrill stapedotomy for otosclerosis with small and large preoperative air-bone gap: a retrospective comparison of results

Andrea Canale,Andrea Albera,Francesco Macocco,Federico Caranzano,Roberto Albera

Publicatie 21-05-2020


In otosclerosis mixed hearing loss is the most frequent symptom and arises when the focus involves the stapes footplate. Surgeons usually prefer to wait a minimum air-bone gap of 25 - 35 dB before surgery.

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Comparison of primary musicality development between children with cochlear implants and children with normal hearing

Meng Wang,Tianqiu Xu,Yan Zhong,Yan Zheng,Jing Lv,Jinye Luo,Chao Meng,Qianqian Guo,Shusheng Gong,Xueqing Chen

Publicatie 02-09-2020


It is beneficial for CI patients listen to music. However it is necessary to take steps to improve the musicality of CI patients.

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Frequency-specific efficacy of intratympanic steroid on idiopathic sudden sensorineural hearing loss

Hideaki Suzuki,Toyoaki Ohbuchi,Ba Hung Do,Thi Nga Nguyen,Tetsuro Wakasugi,Jun-ichi Ohkubo,Takuro Kitamura

Publicatie 05-06-2020


Hearing recovery would be different in each sound frequency in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).

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Treatment of posttraumatic olfactory dysfunction with corticosteroids and olfactory training

Mette Bratt,Kent G. Moen,Ståle Nordgård,Anne-S. Helvik,Toril Skandsen

Publicatie 04-06-2020


Few have investigated long-term effect of treatment of posttraumatic olfactory dysfunction (OD).

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The first experiences of implementation of the Swedish tonsil register in Denmark

Jannik Buus Bertelsen,Therese Ovesen

Publicatie 17-06-2020


Tonsil surgery is a daily procedure at Ear, Nose and Throat (ENT) departments as well as ENT practices. Despite national tonsil guidelines in Denmark, no national survey has been introduced.

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Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer*

Yasutoshi Komatsubara,Tomoyasu Tachibana,Yorihisa Orita,Takuma Makino,Kazunori Kuroda,Yuto Naoi,Yuko Kataoka,Yasuharu Sato,Shin Kariya,Kazunori Nishizaki

Publicatie 04-06-2020


Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.

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Risk factors for aggressive recurrent respiratory papillomatosis in Chinese juvenile patients

Yue Xi,Hua Wang,Wei Wang,Xiaolin Wang,Jie Zhang,Jing Zhao,Guixiang Wang,Jingang Gui,Xin Ni

Publicatie 04-06-2020


Aggressive juvenile-onset recurrent respiratory papillomatosis (JORRP) threatens patient lives if not receives immediate surgical intervene. Even with surgical intervene, complete remission of this disease is not approachable. Therefore, understanding the factors relevant to disease severity and prognosis will do help to the treatment strategy and health management of this disease.

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Matched analysis of the prognosis of amelanotic and pigmented melanoma in head and neck

Wei Guo,Gaofei Yin,Hongfei Liu,Hanyuan Duan,Zhigang Huang,Xiaohong Chen

Publicatie 26-05-2020


The prognosis of mucosal melanoma is poor, and the difference in clinical prognosis between patients with and without pigment needs further study.

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Endoscopic endonasal resection and radiotherapy as treatment for skull base chordomas

Hongbing Li,Huankang Zhang,Li Hu,Huan Wang,Dehui Wang

Publicatie 18-08-2020


The role of endonasal endoscopic surgery and radiotherapy in the treatment of skull base chordomas remains unclear. We investigated the effect of endonasal endoscopic surgery and radiotherapy as treatment for skull base chordomas. We investigated 46 patients (2006-2018) treated at the Affiliated Eye Ear Nose and Throat Hospital, Fudan University. We documented demographics, clinical presentation, operative resection, complications, postoperative radiotherapy, follow-up time, and survival in all patients. Complete tumour resection was performed in 18 (39.1%), subtotal tumour resection in 16 (34.8%), and partial tumour resection in 12 (26.1%) patients. Most common clinical manifestations included nasal obstruction (41%), headaches (30%), and visual impairment (20%). The median duration of progression-free survival (PFS) and overall survival (OS) was 21.5 and 33.5 months, respectively. Primary vs. recurrent disease ( Surgery is the primary treatment for chordoma; higher tumour resection rates are associated with higher OS and PFS. Surgeons should aim to resect as much tumour as is safely possible. Postoperative radiotherapy is useful adjuvant treatment to improve OS, and IMRT serves as an effective alternative to PBRT.The optimal radiotherapeutic technique is determined by cost, accessibility, availability of the modality, and tumour volume.

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Patients with cutaneous head and neck melanoma, particularly elderly with more advanced primary tumors, seem to benefit from initial CT staging before considering a sentinel lymph node biopsy

Anna Hafström,Behzad Nateghi-Gillberg,Margareta A. Nilsson,Lennart Greiff

Publicatie 12-06-2020


The role of CT scanning at the time of diagnosis for patients with primary cutaneous head and neck melanoma (cHNM) clinically asymptomatic for metastatic disease remains unclear.

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Circulating microRNAs as potentially new diagnostic biomarkers of idiopathic sudden sensorineural hearing loss

Sun Mok Ha,Kyu Rin Hwang,Il Hwan Park,Sunyoung Park,Jin Sil Choi,Dong Jun Park,Jeong-Eun Park,Su Hoon Lee,Hye Young Lee,Young Joon Seo

Publicatie 03-09-2020


Early detection of inner ear cell damage can reduce the chances of permanent damage to hearing ability. However, current inner ear cell damage detection methods can detect damage only after the patient has lost hearing ability. MicroRNA expression levels in circulating systems are affected in diseases or conditions arising from the distant lesions. Therefore, detection of circulating microRNA expression levels could be one of the best ways to obtain information on inaccessible lesion sites. This study aims to establish a method for monitoring idiopathic sudden sensorineural hearing loss (ISSNHL) by analyzing circulating microRNA expression levels. 21 ISSNHL patients and 24 healthy controls were enrolled. Real-time quantitative polymerase chain reaction was performed for detecting expression levels of circulating microRNAs. Among eight circulating microRNAs, expression levels of five circulating microRNAs significantly differed between ISSNHL patients and healthy controls. circulating microRNA expression levels correlates with treatment outcomes and hearing ability. Using methods combining the evaluation of miR-183, miR-210, miR-18b, and miR-23a cut-off values identified in ISSNHL patients and healthy controls during receiver operating characteristic curve analysis, sensitivity and specificity of 80.95% (17/21) and 87.50% (21/24) were obtained, respectively.

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Evaluation of high frequency horizontal VOR parameters in patients with chronic bilateral and unilateral peripheral vestibulopathy: a preliminary study

Gulce Kirazli,Sevinc Hepkarsi,Tayfun Kirazli

Publicatie 31-08-2020


Caloric test is one of the tests which evaluates the low frequency component of vestibular system for both diagnosis of the BPV and UPV. The main objectives are to determine and increase the diagnostic value of BPV and UPV by evaluating the high frequency horizontal VOR parameters with HIMP, SHIMP and fHIT, to compare test results with healthy controls, and to evaluate correlation of these tests with vertigo dizziness imbalance (VDI) questionnaire results in these patients. Six patients with BPV, ten patients with UPV and fifteen healthy controls were recruited. High frequency hVOR were evaluated with HIMP, SHIMP and fHIT. Vestibular symptoms and quality of life were assessed with VDI Questionnaire. Lower percentage of correct answers, and lower VOR gains were obtained in affected sides for BPV and UPV. HIMP elicited compensatory saccades in patients, whereas SHIMP elicited large anticompensatory saccades in controls and unaffected side of UPV, but no saccades in BPV. No correlation was found between VDI outcomes and all tests. The results show that all tests are complementary each other and able to identify the affected labyrinth and to show residual vestibular function. These tests are thought to be important in the vestibular rehabilitation process.

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Endoscopic sphenopalatine artery electrocoagulation for refractory epistaxis: a clinical study

Liang Yu,Xiaofei Li,Shujuan Sun,Li Shi,Yuzhu Wan

Publicatie 01-09-2020


The electrical coagulation of sphenopalatine artery(SPA) under nasal endoscopy has gradually become an important surgical intervention for epistaxis. To investigate the effectiveness and complications of SPA electrocoagulation for epistaxis. The clinical data of 47 patients undergoing SPA electrocoagulation were analyzed, retrospectively. Forty-seven patients were enrolled, with a male to female ratio of approximately 3:1. 11of 36 were under 45 years old, 25 of 36were 45 years old and above. Among female patients, one was under 45 years old, and the others were 45 years old and above, but there was no significant difference in gender composition between different age groups ( Refractory epistaxis has no relationship with age and sex, SPA electrcoagulation can effectively control refractory epistaxis and is an effective surgical method.

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Skull vibration-induced nystagmus in vestibular neuritis

Angel Batuecas-Caletrío,Ramón Martínez-Carranza,Gianni Mercy García Nuñez,Maria José Fernández Nava,Hortensia Sánchez Gómez,Santiago Santacruz Ruiz,Vanesa Pérez Guillén,Nicolás Pérez-Fernández

Publicatie 01-09-2020


As described by Dumas, an 80-100 Hz vibration applied to the mastoid produces a horizontal nystagmus, with quick phases beating away from the affected side in patients with unilateral vestibular loss (UVL). To elucidate the characteristics of skull vibration-induced nystagmus (SVIN) in patients suffering from vestibular neuritis and how these characteristics are related to information provided by the video head impulse test (vHIT). Sixty-three patients were enrolled to perform a vHIT to measure the gain in both ears. SVIN was induced with stimulation at 30 Hz, 60 Hz, and 100 Hz. The slow phase velocity (SPV) of the SVIN was measured. The SVIN test was positive in 25/63 patients at 30 Hz, 36/63 at 60 Hz and 46/63 at 100 Hz. Mean gain difference between both ears to obtain a positive SVIN at 30 Hz was observed to be 0.38 ± 0.25, decreasing to 0.35 ± 0.23 at 60 Hz, and 0.31 ± 0.24 at 100 Hz ( There is a close relationship between the difference in the gains of both ears as measured using VHIT and the SPV of the nystagmus induced by SVIN at 100 Hz.

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Facial nerve paralysis in malignant otitis externa: comparison of the clinical and paraclinical findings

Sasan Dabiri,Narges Karrabi,Nasrin Yazdani,Ahmad Rahimian,Azita Kheiltash,Mehrdad Hasibi,Elham Saedi

Publicatie 28-08-2020


Malignant otitis externa is an uncommon but critical challenging disease with some degree of cranial nerve involvement. to examine the factors leading to facial paralysis in these patients and clarify indications for aggressive treatment in the group most at risk. In a case-control study, demographic, clinical, laboratory, audiometric, imaging, and treatment characteristics of 139 patients in groups with and without facial paralysis were analysed. 45 patients (32.4%) had facial paralysis. Compared to patients without facial nerve involvement, patients with facial palsy had a higher rate of inflammatory markers (mean erythrocyte sedimentation rate on admission [67.71 vs 51.16 mm/h], and the average of total ESR [64.27 vs 54.46 mm/h], as well as the mean C-reactive protein [38.96 vs 27.53 mg/L]). Also, the involvement of the facial canal ( Nasopharyngeal extension of the inflammation and facial nerve canal erosion might be useful as predictors of facial nerve dysfunction. The elevated erythrocyte sedimentation rate is correlated with the increased risk of facial paralysis, and aggressive medical management is more crucial. Improvement in predicting the outcome of patients with malignant otitis externa.

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Olfactory dysfunction in patients after recovering from COVID-19

Martin Sylvester Otte,Hans Nikolaus Caspar Eckel,Leonard Poluschkin,Jens Peter Klussmann,Jan Christoffer Luers

Publicatie 28-08-2020


Smell and taste disorders occur in COVID-19 with a high prevalence, but little is known about the duration of the symptoms. In particular, studies using validated olfactory tests are very rare to date. The aim of this study was to determine the olfactory function of COVID-19 recoveries by a detailed olfactory test. 91 patients with PCR-confirmed, past COVID-19 disease were included. Olfactory history was taken using a questionnaire. Olfactory function was evaluated with the sniffin' sticks test, tasting function with taste sprays. 80 patients had experienced sudden olfactory loss during the course of disease and at the time of testing, 33 patients subjectively still had an impaired olfactory sense. Around 8 weeks had passed since the onset of symptoms. 45.1% of the tested individuals were still hyposmic according to the olfactory test while 53.8% showed an olfactory performance within the normal range. Patients' self-assessment correlated poorly with the measured olfactory performance. Half of the patients with an olfactory loss as a symptom of COVID-19 still have olfactory impairments after two months, although not all of these patients subjectively notice a restriction. Long-term measurements must confirm whether all affected patients will make full recovery.

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Incidence and risk factors for radioactive iodine-induced sialadenitis

Alvaro Sánchez Barrueco,Fernando González Galán,Ignacio Alcalá Rueda,Jessica Mireya Santillán Coello,María Pilar Barrio Dorado,José Miguel Villacampa Aubá,Manuel Escanciano Escanciano,Lucía Llanos Jiménez,Ignacio Mahillo Fernández,Carlos Cenjor Español

Publicatie 21-08-2020


Radioactive iodine ( To determine the incidence of RAIS, analysing the epidemiological data and tumour- and treatment-related factors that may influence the development of the disease. 197 patients who received radioiodine treatment between 2015 and 2017 were studied (76.6% women). The variables studied were age, gender, weight, height, and body mass index; presence of high blood pressure, dyslipidemia, diabetes, and thyroid diseases; cumulative radioiodine dose, presence of sialadenitis, affected salivary gland, and the time of onset. 14 patients developed sialadenitis (78.6% women), all with DTC. The incidence of sialadenitis was 3.4% overall and 6.3% among DTC patients. Furthermore, we found that higher cumulative radioiodine doses confer a greater risk of developing sialadenitis, with a hazard ratio of 1.009 ( In this series, a dose-dependent relationship was found between radioiodine treatment and sialadenitis.

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Design and application of submental island flap to reconstruct non-circumferential defect after hypopharyngeal carcinoma resection: a prospective study of 27 cases

Wenting Pang,Aobo Zhang,Cheng Lu,Jun Tian,Wan-xin Li,Zhenxiao Wang,Yanbo Dong,Shuoqing Yuan,Zihao Niu,Yiyuan Zhu,M. Shahed Quraishi,Liangfa Liu

Publicatie 19-08-2020


This study investigated the effects of reconstruction of hypopharyngeal non-circumferential defects with a submental island flap after ablation of hypopharyngeal carcinoma. The purpose of our study was to identify advantages and limitations of the submental flap for reconstruction of non-circumferential hypopharyngeal defects. A total of 27 patients who had stage II-IV hypopharyngeal cancer and underwent pharyngeal reconstruction with a submental flap by the senior author in both Department of Otolaryngology Head Neck Surgery, Chinese PLA General Hospital and Department of Otolaryngology Head Neck Surgery, Beijing Friendship Hospital, Capital Medical University. 96.3% (26/27) cases of submental island flap survived. There were two pharyngocutaneous fistulas, one recovered spontaneously, and the other was associated with flap necrosis, underwent neck debridement and flap removal. All except for one patient had decannulation of their nasogastric tube 2 weeks postoperatively. There was no evidence of a stricture or stenosis of the laryngopharynx, nor any sign of aspiration, except for one with esophageal inlet stricture caused by radiotherapy. There were two cases of obvious paraesthesia pharynges due to beard growth at the submental flap after reconstruction. 63.0% (17/27) patients are alive and 37% (10/27) have died of disease. The 3-year survival rate is 56.3% and the 5-year survival rate is 50.0%. The submental flap reconstruction for moderately sized non-circumferential hypopharyngeal defects is a recommended treatment option.

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Nystagmus in patients with lateral semicircular canal dysplasia

BoYoon Choi,Dong-Han Lee,Jung Eun Shin,Chang-Hee Kim

Publicatie 19-08-2020


Dizziness is not a common symptom in the lateral semicircular canal (LSCC) dysplasia, and nystagmus findings has been rarely described in LSCC dysplasia. To investigate the characteristics of spontaneous and positional nystagmus in patients with LSCC dysplasia. Patterns of spontaneous and positional nystagmus of twelve patients with LSCC dysplasia, who visited our clinic with a chief complaint of dizziness, were investigated. LSCC dysplasia was observed unilaterally in 4, and bilaterally in 8 patients. Non-rotatory dizziness with various onset times was the most common description of dizziness, and unilateral caloric weakness was observed in 82% of patients. Direction-fixed nystagmus, in which the direction of spontaneous nystagmus was same with that of positional nystagmus, was observed in 9 patients, and direction-changing positional nystagmus, in which the direction of nystagmus was changed from that of spontaneous nystagmus by positioning maneuvers, was observed in 3 patients, of whom down-beating or direction-changing spontaneous nystagmus was observed in one patient each. While direction-fixed horizontal nystagmus is the most commonly observed type of nystagmus in LSCC dysplasia, atypical spontaneous nystagmus, such as down-beating nystagmus or direction-changing spontaneous nystagmus, may be observed in patients with bilateral LSCC dysplasia.

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Self-reported course of olfactory impairment determines outcome for successful surgical intervention in nasal polyps with anosmia

Wei Zhang,Yifan Meng,Chengshuo Wang,Feifei Cao,Luo Zhang

Publicatie 19-08-2020


Olfactory impairment is one of important symptoms of Chronic rhinosinusitis with nasal polyps (CRSwNP). However, the relationship between course of olfactory impairment and postoperative symptom improvement was still unclear. The aim of this study was to assess the relationship between the self-reported course of olfactory loss and the degree of improvement in olfaction to determine the timing for successful surgical intervention in improving olfaction in patients with CRSwNP. A total of 86 CRSwNP patients with loss of smell and undergoing functional endoscopic sinus surgery (FESS) were recruited consecutively. The self-reported course of smell lose before treatment was recorded. Olfactory function was recorded before and after FESS using T&T Olfactometry. Fifty-seven patients demonstrated recovery of olfaction and 29 patients no-recovery. The average recovery time of smell loss in the study was 2.6 weeks. The course of smell loss showed moderate accuracy as a marker for determining the timing for successful FESS; with up to 4.5 years of self-reported smell loss being the cut-off point for recovery of smell following FESS. This study suggests that FESS in CRSwNP patients with self-reported significant olfactory impairment for less than 4.5 years may lead to improvement in olfaction. FESS in CRSwNP patients with self-reported significant olfactory impairment persisting for less than 4.5 years may lead to considerable improvement in olfaction in these patients.

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Clinical outcome in recurrent and/or metastatic head and neck cancer patients after discontinuation of nivolumab monotherapy due to immune-related adverse events

Ryuji Yasumatsu,Mioko Matsuo,Takahiro Wakasaki,Muneyuki Masuda,Toranoshin Takeuchi,Tomomi Manako,Rina Jiromaru,Ryutaro Uchi,Kazuki Hashimoto,Takashi Nakagawa

Publicatie 19-08-2020


Significant immune-related adverse events (irAEs) requiring therapy discontinuation sometimes occur. The influence of discontinuation on disease control after an irAE is unclear. The aim of this study was to investigate whether or not patients continued to show a response or durable disease control even after stopping therapy following an irAE. The response after nivolumab monotherapy discontinuation was examined for 14 patients in whom therapy was stopped without progression. The best response was CR in 5 (36%) patients, PR in 8 (57%) patients and SD in 1 (7%) patient. The estimated 1-year overall and progression-free survival rates were 92.9% and 78.6%, respectively. The best response during nivolumab therapy in patients who developed PD was CR in 0 of 5 patients (0%), PR in 3 of 8 patients (38%) and SD in 1 patient (100%). Patients obtaining CR tended to have a lower risk of PD than those with PR or SD. Patients with CR status may continue to show a response or durable disease control even after stopping therapy due to an irAE.

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Clinical outcomes of different treatments and risk factors in patients with otogenic brain abscess, a real-world evidence-based retrospective study

Yao Song,Danni Cheng,Ke Qiu,Xiaohong Yan,Jianjun Ren,Jianqing Qiu,Di Deng,Yufang Rao,Yongbo Zheng,Wendu Pang,Yijun Dong,Qiurui Liu,Yanming Ren,Yu Zhao

Publicatie 18-08-2020


Otogenic Brain Abscess (OBA) is a life-threatening complication secondary to otitis media, but its appropriate management remains controversial. To understand the demographic characteristics, management, and variables that affect the outcomes of patients with OBA based on our experiences over 11 years. Clinical data were collected for 41 patients. Prognostic factors associated with mortality were assessed, and clinical outcomes compared among groups receiving different treatments. Among the 41 patients, 19.6% did not undergo surgery, 39.0% were treated with two-stage surgery (otological surgery and neurosurgery) and 41.4% were treated with single-stage surgery (otological surgery or neurosurgery). Overall mortality rate was 32.5%, and mortality was significantly higher in patients with invasion of the petrous apex (odds ratio [OR]: 7.81, 95% confidence interval [95% CI]: 1.26-48.36), and lower in those with appropriate surgical management (single otological surgery, OR: 0.07, 95% CI: 0-0.97; single neurosurgery, OR: 0.13, 95% CI: 0.02-1.0; two-stage surgery, OR: 0.08, 95% CI: 0.01-0.64) or a higher Glasgow Coma Scale (GCS) score at admission (OR: 0.64, 95% CI: 0.44-0.93). Data on invasiveness and pre-surgery GCS greatly aid in predicting the prognosis of OBA patients. Early evaluation will facilitate decision-making by physicians treating OBA patients.

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Prevalence of occult cochlear basal turn patency

Varun V. Varadarajan,Orrin L. Dayton,Reordan O. De Jesus,Patrick J. Antonelli

Publicatie 18-08-2020


Perilymph gusher (PLG) is a rare complication of otologic surgery attributed to a communication between the cochlea and the internal auditory canal (IAC). Subtle patency between the cochlear basal turn and IAC has recently been identified on computed tomography (CT) as a risk factor, specifically when the defect is > 0.75 mm. Investigate the prevalence of radiographic cochlear basal turn patency. Patients with CT of the temporal bones and inner ears interpreted as "normal" were included. An otologist and a radiologist independently reviewed CTs to measure radiographic dehiscence in an oblique plane along the interface of the cochlea and IAC. Known PLGs were excluded. Two hundred and ten ears were included (88 conductive or mixed hearing loss, 62 sensorineural hearing loss, 41 audiometrically normal ears). 71 ears (33.8%) were radiographically patent. Mean defect width was 0.41 mm (0.15-0.7 mm). Defect width was not associated with type of hearing loss, age, or gender. No defects were wider than 0.75 mm. Radiographic patency of the cochlear basal turn may be present in patients with hearing loss and normal hearing, but patency > 0.75 mm (i.e. risk for PLG) is rare.

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Comparison of frequency-specific hearing outcomes after endoscopic and microscopic tympanoplasty

Lingchao Ji,Suoqiang Zhai

Publicatie 18-08-2020


Hearing results of endoscopic and microscopic tympanoplasty have been compared using the average pure tone threshold which could conceal subtle differences at a specific frequency. To compare frequency-specific hearing outcomes of endoscopic and microscopic tympanoplasty. The study included 42 patients who underwent endoscopic or microscopic type I tympanoplasty. The medical charts of these patients were reviewed retrospectively. We evaluated the pure tone audiometry at 250, 500, 1000, 2000 and 4000 Hz, including bone conduction (BC), air conduction (AC) and air-bone gap (ABG) before and after the surgery. The main outcome measures were frequency-specific pre- and post-operative hearing thresholds and the corresponding changes. We also assessed the graft success rate and surgical complications. BC revealed a significant aggravation at 4000 Hz in microscopic tympanoplasty group, but no significant differences between the two groups at any frequencies. Both groups showed improvements in AC and ABG at all frequencies, without significant differences between the two groups at any single frequency. The maximum improvement of AC and ABG was found at 250 Hz. The graft success rate and operative complications were also similar. The frequency-specific hearing outcomes of endoscopic and microscopic tympanoplasty are similar.

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Video head impulse testing in patients with benign paroxysmal positional vertigo

Ziya Saltürk,Sertaç Yetişer

Publicatie 18-08-2020


Vestibulo-ocular reflex (VOR) function is expected to be normal in patients with benign paroxysmal positional vertigo (BPPV) during sudden head rotations. The aim of this study is to analyze VOR by video head impulse test (vHIT) in patients with BPPV in order to determine the potential value of clinical application of vHIT in BPPV. Sixty patients with BPPV were included for the study from out-patient admissions. The main outcome measures were the gain of VOR, gain asymmetry, and refixation saccades. Fifteen healthy subjects with no history of dizziness were selected as normal control. Mean VOR gain during lateral head impulse in patients with geotropic type LC BPPV was 0.85 ± 0.22. Mean VOR gain during lateral head impulse in patients with ageotropic type LC BPPV was 0.78 ± 0.16. Fourteen patients with PC BPPV (35%; 40/13) had low gain during ipsilesional head impulses. Seven patients had low gain during counterlesional head impulses. Mean VOR gain during vertical head impulse in patients with PC BPPV was 0.73 ± 0.24. Nine patients with posterior canal BPPV (25%; 9/40) and 2 patients with LC BPPV (11%; 2/18) had corrective saccades. None of the results showed significant difference in comparison to control group. VHIT analysis demonstrated that VOR function was normal on the BPPV side.

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Measurement of stapes footplate thickness in otosclerosis by ultra-high-resolution computed tomography

Yukinori Akazawa,Akira Ganaha,Teruyuki Higa,Shunsuke Kondo,Yoshiki Oyakawa,Hitoshi Hirakawa,Mikio Suzuki,Tsuneo Yamashiro

Publicatie 24-07-2020


Ultra-high-resolution computed tomography (U-HRCT) utilizes a 1024 × 1024 matrix with 0.25-mm section thickness, offering better spatial resolution than conventional multi-detector row CT to detect anatomic data for otologic surgery. We examined stapes footplate thickness using U-HRCT in relation to stapedotomy to predict the difficulty of the surgical procedure. Subjects were 12 otosclerosis patients and 25 controls who underwent diagnostic U-HRCT. A profile curve (Hounsfield units) was used to measure stapes footplate thickness along a perpendicular line across the stapes footplate in a plane parallel to the lateral semicircular canal. Footplate thickness was smaller at the midpoint than just before the anterior crus and just after the posterior crus. Interobserver variability was lowest at the midpoint, where foot plate thickness was significantly greater in the affected ear in otosclerosis patients compared with controls (0.60 ± 0.09 mm vs 0.46 ± 0.04 mm; Footplate thickness on U-HRCT correlated with temporal bone anatomy and corresponded to surgical difficulty.

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Surgical management of cochlear implant in chronic otitis media patients: safe and sound

Bee See Goh,Dayaabaran Marimuthu,Wan Fazlina Wan Hashim,Asma Abdullah

Publicatie 22-07-2020


Cochlear implantation (CI) in cases with chronic otitis media (COM) was previously contraindicated but recent advances have made it possible. To review surgical and audiological outcomes of COM patients that underwent CI. Retrospective review of patients above 18 years old. Ten patients with complete data were included. Patients were aged 24-69 years old. Tympanoplasty and mastoidectomy were performed before CI. Imaging was performed to rule out ossifications. Eight patients underwent a standard canal wall up with either cochleostomy or round window approach. One patient had additional canalplasty and tympanoplasty and another one had blind sac procedure respectively. Analysis of the hearing aided level with CI and hearing aid showed significant benefit provided by the CI ( Creating a dry and safe ear is important prior to CI. Definite hearing improvement is seen in all our cases that helped them to become independent again in their daily life. Hearing aid usage pre-CI might not be important as the hearing aids may continue to cause discharging ears and the benefits of hearing aids in severe to profound hearing loss are very minimal. Cochlear implant is safe and effective in COM patients.

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The impact of stapes surgery on osteogenesis imperfecta: a retrospective comparison of operative outcomes with those for patients with otosclerosis

Xiaoyan Ma,Fangyuan Wang,Weidong Shen,Shiming Yang

Publicatie 22-07-2020


While stapes surgery has long been employed as a means of improving hearing in patients with otosclerosis, it remains controversial as to whether such surgical intervention is of value in patients with osteogenesis imperfecta (OI). This study was therefore designed to determine whether stapes surgery could still be reliably performed in OI patients as it is in otosclerosis patients. Seventeen OI patients and 18 matched otosclerosis patients were included. In both of these groups, 22 ears underwent primary stapes surgery. Audiometric follow-up data for patients in these two treatment groups were available for between 2 weeks and 25 years post-surgery. We detected significant improvements in both the short- and long-term mean air conduction threshold and reduced air-bone gap (ABG) in both treatment groups as measured via postoperative follow-up audiometry. There was no difference between the OI and otosclerosis patient groups with respect to short- and long-term postoperative audiometric.

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Scutum reconstruction technique and classification in endoscopic middle ear cholesteatoma surgery

Nan Wu,Wenjing Zuo,Fangyuan Wang,Kun Hou,Shiming Yang,Zhaohui Hou

Publicatie 22-07-2020


Endoscopy has been increasingly used in middle ear cholesteatoma surgery. It can increase the proportion of canal wall up (CWU) surgery and effectively control the recurrence and residual rates. However, there is a lack of systematic description on scutum reconstruction technique in endoscopic middle ear cholesteatoma surgery. The technique and classification of scutum reconstruction in endoscopic cholesteatoma surgery were proposed, and the outcomes were preliminarily evaluated. According to the development of mastoid and the way of hearing reconstruction, the reconstruction of scutum was classified into three types. The rates of residual and recurrence and hearing outcomes were observed and analyzed. A total of 57 patients underwent endoscopic cholesteatoma surgery, all of which were CWU surgery. The reconstruction of the scutum was performed using tragal cartilage according to three types. The residual of cholesteatoma was observed in three cases. The recurrence of cholesteatoma and retraction pocket was detected in two cases and five cases, respectively. Postoperative hearing results were generally satisfied in all three types of surgeries. The technique of scutum reconstruction in endoscopic cholesteatoma surgery in this work can effectively control the recurrent disease after CWU surgery.

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Comparison between high-resolution 3D-IR with real reconstruction and 3D-flair sequences in the assessment of endolymphatic hydrops in 3 tesla

Víctor Manuel Suárez Vega,Pablo Dominguez,Fanny Meylin Caballeros Lam,Jose Ignacio Leal,Nicolás Perez-Fernandez

Publicatie 22-07-2020


The main sequences used to assess degree of endolymphatic hydrops (EH) are the 3D- inversion-recovery (IR) with real reconstruction and the 3D- fluid-attenuated inversion recovery (FLAIR). The purpose of this study is to describe and compare both sequences. Forty-two consecutive patients diagnosed with probable or definite Ménièr´s disease were referred for hydrops MR examination. Vestibular and cochlear EH in both sequences were read by two independent radiologists, unaware of the patient's clinical status. The primary study endpoint was the concordance in the hydrops detection and severity with both imaging sequences. This was assessed using the Cohen's kappa Κ statistic for disease grading and Pearson Χ We obtained an excellent overall concordance, with a kappa of 0.821, ( The 3D-IR sequence seems to be superior to the 3D-FLAIR for the assessment of EH.

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Radiotherapy versus laser microsurgery in the treatment of early glottic cancer

Yolanda Lois-Ortega,Fernando García-Curdi,José Miguel Sebastián-Cortés,Félix De Miguel-García,Héctor Vallés-Varela,Ana Muniesa-del Campo

Publicatie 18-07-2020


Glottic squamous cell carcinoma (SCC) in stages I or II can be treated by transoral CO To compare the oncological results of patients treated with TLM, to those treated with RT, in a tertiary hospital. Data from patients diagnosed with glottic SCC in stages I and II between 2004 and 2018 were analyzed. Response to treatment was studied in terms of recurrence, local control and laryngeal preservation. Of 164 patients, 63.41% received treatment with TLM and 36.58% with RT. 26.21% presented a recurrence or progression of the tumor. Both treatments obtained good local control rates (84.15% in the case of TLM and 89.6% in the case of RT) and no significant association was found between tumor recurrence and type of treatment, nor with the involvement of the anterior commissure. However, treatment with RT obtained worse laryngeal preservation rate compared to TLM (81.6% and 100% respectively) (

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Biomechanical analysis of the clinical characteristics of enlarged vestibular aqueduct syndrome with Mondini malformation

Jia-Wei Han,Lin Wang,Hui Zhao,Shi-Ming Yang

Publicatie 15-07-2020


numerous researches on the pathological mechanism of Enlarged Vestibular Aqueduct (EVA) syndrome mainly focuses on the genetic characteristics of To establish a new approach to explain the clinical manifestations of EVA syndrome with biomechanical method. 108 cases of EVA syndrome who received cochlear implantation were analyzed retrospectively. A cochlear model was built to reflect the differences of the structure in EVA syndrome with or without Mondini malformation. The CFD software was used to simulate and display the differences in mechanical pathogenic factors to which the model was subjected. EVA syndrome patients with Mondini malformation suffer more mechanical damage from the cerebrospinal fluid pressure due to their structural reason and their symptoms appear earlier and progress faster. Biomechanics is an important aspect of pathological mechanism of EVA syndrome, and it provides a new angle for clinical decision-making.

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Incidence and impact of dysplasia at final resection margins in cancers of the oral cavity

Arjun Singh,Manish Mair,Hitesh Singhvi,Natarajan Ramalingam,Munita Bal,Komal Lamba,Deepa Nair,Sudhir Nair,Pankaj Chaturvedi

Publicatie 15-07-2020


The literature often cites margin status as being free, close or involved by tumor but there is very sparse evidence of the relevance of dysplasia at resection margin. This is a retrospective review of 1700 treatment naïve oral squamous carcinoma patients who underwent surgery between January 2012 and December 2015. The study arm consisted of patients with dysplasia at final resection margin (D-FRM). Each of these patients were double propensity matched to obtain positive (P-FRM), close (C-FRM) and free final resection margins (F-FRM). There was no hazard discrimination in survival among the D-FRM and C-FRM (vs F-FRM; p-0.597, HR-1.207 (0.621-2.346) and p-0.075, HR-1.594 (0.947-2.684), respectively). A decreasing survival trend was observed as the grade and number of D-FRM margins increased. Although not significant, the addition of adjuvant therapy for D-FRM showed a trend towards improved survival outcomes compared to C-FRM, especially with chemotherapy.

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Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders

Kyoko Morimoto,Tadao Yoshida,Masumi Kobayashi,Satofumi Sugimoto,Naoki Nishio,Masaaki Teranishi,Shinji Naganawa,Michihiko Sone

Publicatie 11-07-2020


High signal intensity in the endolymphatic duct (ED) is occasionally observed on magnetic resonance imaging (MRI) in ears that have otological disorders. The signal intensity (SI) in the ED on post-contrast MRI was investigated in subjects with various otological disorders, and the meaning of high SI in the ED was evaluated. 392 patients with otological disorders and 21 controls without otological symptoms underwent 3 T MRI. The SIs of the ED and the cerebellum were measured, the SI ratio (SIR) was calculated, and ears with SIR ≥4 were identified. A high SIR was identified in the ED of 3.7% of ears affected by definite Meniere's disease (dMD), 100% of ears affected by large vestibular aqueduct syndrome (LVAS), and 7.1% of ears with no otological symptoms. On the whole, a significant relationship was found between the existence of vestibular or cochlear EH and the SIR in the ED. The MRI finding of high SI in the ED may indicate the mechanism of inner ear disturbances in ears with otological disorders, especially in those with LVAS, and it may suggest an underlying disorder in some ears in which otological symptoms are not apparent.

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Endoscopic myringoplasty in pediatric patients: a comparison of cartilage graft push-through and underlay fascia graft techniques

Zhengcai Lou

Publicatie 12-07-2020


Although myringoplasty is performed in pediatric patients, there is still no consensus on the graft material and surgerical procedure. To compare the short-and long- term graft take rates of the cartilage push-through and fascia graft techniques employed during pediatric myringoplasty. 93 pediatric patients with perforation who underwent myringoplasty were randomized into the cartilage push-through and underlay fascia graft group. The outcomes evaluated were hearing gains, and graft success rates at 12 and 24 months. The graft success rate was similar between two groups (95.7% vs 91.3%, Endoscopic cartilage push-through and underlay fascia graft myringoplasty afforded comparable hearing results in pediatric patients; however, the push-through technique without the elevation of a tympanomeatal flap exhibited better long-term graft success rate compared to underlay fascia graft.

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Development of depression in patients with oral cavity cancer: a systematic review

Mira Westphal Lansner,Kathrine Kronberg Jakobsen,Jakob Schmidt Jensen,Karl Erik Sandsten,Christian Grønhøj,Christian von Buchwald

Publicatie 10-07-2020


The incidence of oral cancer is approximately 300,000 patients annually. A cancer diagnosis and treatment affect both physical and mental issues. The aim of this systematic review was to examine the development of depression in patients who have been treated for oral squamous cell carcinoma (OSCC). PubMed and EMBASE were systematically searched for studies addressing depression among patients treated for OSCC and published within the past ten years. We identified three studies comprising 528 patients (range: 75-349), primarily men (66-83%), treated for OSCC from Europe and India. Tumour stage, treatment modality, and scales used to evaluate depressive symptoms varied in the studies. The European studies showed that 28% of the patients experienced depressive symptoms on the Hospital Anxiety and Depression Scale (HADS) and a mean of 8.0 on depression in the Brief Symptom Inventory (BSI). The Indian study showed a significant increase (

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Phoneme recognition in bimodal hearing

Talma Shpak,Tova Most,Michal Luntz

Publicatie 10-07-2020


Many unilateral cochlear implant (CI) users have residual hearing in the nonimplanted ear, allowing them to use bimodal hearing. Assessing the hearing aid (HA) contribution is important. To examine the contribution of a contralateral HA in unilateral CI users with severe-profound hearing loss (HL) in the non-implanted ear to phonetic features perception. For all consonants and vowel features, participants scored better in the bimodal condition than in the CI-alone condition. Better low frequencies thresholds in the HA ear correlated with better perception of phonetic features in the bimodal condition. CI/HA users with only minimal speech recognition using HA alone in the nonimplanted ear extract low-frequency information provided by the HA ear and combine it with information coming from the implanted ear.

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Incidence of thyroid gland invasion in advanced laryngeal cancers and its impact on disease-specific survival; a retrospective review at a tertiary care center

Tahir Muhammad,Rahim Dhanani,Sameen Mohtasham,Muntazir Hussain,Muhammad Faisal,Kashif Iqbal Malik,Arif Jamshed,Raza Hussain

Publicatie 08-07-2020


Incidence of thyroid gland invasion in advanced laryngeal cancers is low. Ipsilateral or total thyroidectomy along with total laryngectomy has been controversial and there has been no consensus over the management of thyroid gland in advanced laryngeal cancers.

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Pathophysiology of the COVID-19 – entry to the CNS through the nose

Jukka Ylikoski,Marika Markkanen,Antti Mäkitie

Publicatie 01-07-2020


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Using betahistine in the treatment of patients with Menière’s disease: a meta-analysis with the current randomized-controlled evidence

Louise Devantier,Dan Hougaard,Mina Nicole Händel,Frank Liviu-Adelin Guldfred,Jesper Hvass Schmidt,Bjarki Djurhuus,Henriette Edemann Callesen

Publicatie 26-06-2020


Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist.

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Impact of surgical resection margins less than 5\u2009mm in oral cavity squamous cell carcinoma: a systematic review

Alexandra Bungum,Jakob Schmidt Jensen,Kathrine Kronberg Jakobsen,Anders Christensen,Christian Grønhøj,Christian von Buchwald

Publicatie 23-06-2020


The width of the surgical resection margin impacts recurrence and survival in oral cavity squamous cell carcinoma (OSCC). The most commonly used definition of a clear margin is one larger than 5 mm, although due to anatomical restrictions to e.g. bone or vessels, this size is not always feasible. Margins less than 5 mm affect postsurgical strategies and prognoses, and further knowledge of margins smaller than 5 mm is needed.

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Dexamethasone protects the hearing of Meniere’s disease patients after triple semicircular canal plugging

Yafeng Lyu,Daogong Zhang,Xiaofei Li,Yuechen Han,Yawei Li,Jing Wang,Yongdong Song,Ligang Kong,Huirong Jian,Zhaomin Fan,Haibo Wang

Publicatie 23-06-2020


TSCP has shown its efficacy in vertigo control for intractable Meniere's disease. However, hearing impairment remains a problem and hampered the application of the surgery.

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The outcomes of bilateral cochlear implant users in Universiti Kebangsaan Malaysia

Haziq Hakimi Mohammad Azmi,Bee See Goh,Asma Abdullah,Cila Umat

Publicatie 23-06-2020


Bilateral cochlear implants are seen to improve hearing capabilities. To assess the auditory outcome of paediatric bilateral cochlear implant in Universiti Kebangsaan Malaysia. This was a cross-sectional and descriptive study single centre analysis. Categories of Auditory Performance (CAP-II) scale and Speech, Spatial and Qualities (SSQ) of Hearing questionnaire were used. Forty-six patients were recruited. Majority of the children (30.4%) rated 7 and 23.9% scored perfectly (9) based on the CAP-II Scale. The least performing children were rated 5 (average). Children that were implanted sequentially within 24 months showed median CAP-II scale of 7. No significant correlation seen between CAP-II and the duration interval, use and age of 1st CI ( Bilateral CI have shown benefits in auditory performance even though majority were performed sequentially. Promising outcome was better with prolonged usage of the device. Hearing in noise is significantly better in bilateral CI.

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Current status on researches of Meniere’s disease: a review

Yupeng Liu,Jun Yang,Maoli Duan

Publicatie 23-06-2020


Meniere's disease (MD) is a complex and multifactorial inner ear disease. The etiology of MD is unclear. Significant progress had been made in diagnosis and treatment. Complete cure for this disease is still impossible.

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Contralesional subjective visual horizontal predicts endolymphatic hydrops

Benjamin Nham,Miriam S. Welgampola,G. Michael Halmagyi

Publicatie 20-06-2020


The subjective visual horizontal (SVH) is a test of utricular function that assesses conjugate ocular torsion which is a component of the ocular tilt reaction (OTR). In unilateral destructive peripheral vestibular lesions, the OTR and so the SVH tilt is usually ipsiversive.

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Cognitive-behavioural therapy for chronic subjective dizziness: Predictors of improvement in Dizziness Handicap Inventory at 6 months posttreatment

Yuko Toshishige,Masaki Kondo,Kayoko Kabaya,Wakako Watanabe,Ayako Fukui,Junya Kuwabara,Meiho Nakayama,Shinichi Iwasaki,Toshi A. Furukawa,Tatsuo Akechi

Publicatie 17-06-2020


Chronic subjective dizziness (CSD), which was superseded by persistent postural-perceptual dizziness as of 2017, has a great impact on patients' quality of life. Cognitive-behavioural therapy (CBT) is a promising treatment, with demonstrated effectiveness as a CSD treatment; however, no studies have examined positive predictors of its effectiveness in the long term.

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Sleep-related deglutition and respiratory phase patterns in the aged with obstructive sleep apnea under CPAP therapy

Kiminori Sato,Shun-ichi Chitose,Kiminobu Sato,Fumihiko Sato,Takeharu Ono,Hirohito Umeno

Publicatie 17-06-2020


Respiratory phase patterns associated with deglutition and clearance of pharynx by deglutition are important in protecting airways and lungs against aspiration.

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Cholesteatoma debridement for primary external auditory canal cholesteatoma with non-extensive bone erosion

Guanwen He,Zhongshou Zhu,Wenhui Xiao,Rifu Wei,Liwen Chen,Yangbin Xu,Ping Liu,Huifeng Li

Publicatie 10-06-2020


External auditory canal (EAC) cholesteatoma (EACC) is rare and its treatment for different lesions has not yet been standardized.

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