JAMA Otolaryngology Head and Neck Surgery 2021-07-01

Error in Affiliations

Publication date 01-07-2021


In the Letter to the Editor titled “Regarding Use of Povidone Iodine to Reduce Nasopharyngeal Viral Load in Patients With COVID-19” published in the April 29, 2021, issue of JAMA Otolaryngology–Head Neck Surgery, there was an incorrect affiliation for Dr Yadov. The correct affiliation is the Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. This article was corrected online.

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JAMA Otolaryngology–Head & Neck Surgery

Publication date 01-07-2021


Mission Statement: JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions that will enhance the clinician’s understanding of otolaryngologic disorders, benefit the care of our patients, and stimulate research in our field; (2) forecast important advances within otolaryngology–head and neck surgery, particularly as they relate to the prevention, diagnosis, and treatment of disease through clinical and translational research, including that of the human genome and novel imaging techniques; (3) address questions of clinical outcomes and cost-effectiveness that result from clinical intervention, which grow in importance as health care providers are increasingly challenged to provide evidence of enhanced survival and quality of life; (4) provide expert reviews of topics that keep our readers current with true advances and also to provide a valuable educational resource for trainees in the several disciplines that treat patients with diseases of the head and neck; (5) serve as a forum for the concerns of otolaryngologists such as socioeconomic, legal, ethical, and medical issues; (6) provide helpful critiques that enable contributing authors to improve their submissions. We encourage a concise presentation of information and employ an abstract format that efficiently assesses validity and relevance from a clinical perspective. This approach promotes succinct yet complete presentation for our readers and electronic information resources. We believe this approach typifies the commitment of JAMA Otolaryngology–Head & Neck Surgery to providing important information that is easily interpreted by its diverse readership.

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Nasal Septal Abscess Resulting From Poorly Fitting Dentures

Trojan JD, Barton B, Mandin V, et al.

Publication date 01-07-2021


This case report describes a woman in her 50s who presented with nasal septal abscess resulting from poorly fitting dentures that resulted in translocation of oral flora into the nasal septum.

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Tracheostomy and Outcomes in Patients With COVID-19 and SARS-CoV-2 Transmission Among Health Care Professionals

Staibano P, Levin M, McHugh T, et al.

Publication date 01-07-2021


This systematic review and meta-analysis examines the association of tracheostomy with COVID-19 patient outcomes and the risk of SARS-CoV-2 transmission among health care professionals.

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Hearing Loss, Pulsatile Tinnitus, and Otalgia

Chapel A, Page J, Sweeney AD.

Publication date 01-07-2021


A 54-year-old woman with a history of hypertension, hyperlipidemia, and migraines presents with worsening right ear pain, pulsatile tinnitus, and hearing loss while denying fever, otorrhea, prior ear infections, vertigo, or otologic surgery. What is your diagnosis?

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Preliminary Analysis of Association Between COVID-19 Vaccination and Sudden Hearing Loss

Formeister EJ, Chien W, Agrawal Y, et al.

Publication date 01-07-2021


This cross-sectional study examines the national incidence of sudden sensorineural hearing loss after COVID-19 vaccination using data from the CDC Vaccine Adverse Events Reporting System.

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Effects of Auditory Stimulation on Pain and Agitation on Awakening After Pediatric Adenotonsillectomy

Muzzi E, Ronfani L, Bossini B, et al.

Publication date 01-07-2021


This randomized clinical trial determines the effects of intraoperative auditory stimulation on reduction of pain on awakening and emergence delirium after pediatric adenotonsillectomy.

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Trend Analysis of Cutaneous Squamous Cell Carcinoma of the External Lip

Mehta NK, Nguyen SA, Chang BA, et al.

Publication date 01-07-2021


This cohort study analyzes data obtained from the Surveillance, Epidemiology, and End Results registry to assess trends across the last 4 decades in incidence, survival outcomes, and clinical, demographic, and treatment characteristics among patients with cutaneous squamous cell carcinoma of the external lip.

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Costs Associated With Imaging Surveillance After Head and Neck Cancer Treatment

Nocon CC, Kennedy A, Jaffe J, et al.

Publication date 01-07-2021


This economic evaluation assesses practice patterns in surveillance imaging in patients with head and neck cancer and evaluates the costs associated with these imaging practices.

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Fluorescence Imaging to Identify Occult and Ectopic Parathyroid Glands—Revealing the Unseen

Hom ME, Rosenthal EL.

Publication date 01-07-2021


In this issue of JAMA Otolaryngology—Head & Neck Surgery, Kennedy and colleagues describe intraoperative molecular imaging (IMI) using the near-infrared (NIR) agent indocyanine green (ICG) to identify parathyroid glands. One of the most important contributions of this study is that it directly compares 2 methods of fluorescent imaging—use of autofluorescence (“label-free”) vs use of ICG as a contrast agent. The use of IMI demonstrated superior signal-to-background ratios (SBRs) compared with autofluorescence. Excitingly, in the 2 patients who underwent reexploration parathyroidectomy, IMI successfully localized the ectopic parathyroid gland, which could not be identified by conventional methods. These results suggest that IMI is an accurate and reproducible method for localizing parathyroid glands and that ICG imaging is superior to autofluorescence for parathyroid gland identification.

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Use of Near-Infrared Molecular Imaging For Localizing Visually Occult Parathyroid Glands in Ectopic Locations

Kennedy GT, Azari FS, Newton AD, et al.

Publication date 01-07-2021


This proof-of-principle clinical trial examines use of intraoperative molecular imaging for localizing visually occult parathyroid glands in both anatomic and ectopic locations.

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Risk Factors of Voice and Speech Symptoms Among Long-term Survivors of Oropharyngeal Cancer

Aggarwal P, Hutcheson KA, Garden AS, et al.

Publication date 01-07-2021


This cross-sectional study examines risk factors of voice and speech symptoms among survivors of long-term oropharyngeal cancer.

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Complications of COVID-19 Nasopharyngeal Swab Test

Koskinen A, Tolvi M, Jauhiainen M, et al.

Publication date 01-07-2021


This case series investigates the frequency and type of SARS-CoV-2 nasopharyngeal test complications in Helsinki, Finland.

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Regarding Use of Povidone Iodine to Reduce Nasopharyngeal Viral Load in Patients With COVID-19

Singh A, Yadav M, Sikka K.

Publication date 01-07-2021


To the Editor We read with interest the recent article by Guenezan et al, “Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial,” published in JAMA Otolaryngology–Head and Neck Surgery on the use of nasal and oral application of 1% povidone iodine (PVP-I) solution in nonadmitted patients with COVID-19. We congratulate the authors for publishing this highly relevant clinical data pertaining to the ongoing pandemic. Despite the rollout of safe vaccination, the final outcome of SARS-CoV-2 remains to be seen. Until the definitive data emerges (possibly even beyond then), the importance of preventive strategies cannot be overemphasized. The wide availability and antimicrobial spectrum (including virucidal properties against SARS-CoV-2 demonstrated in the in vitro studies) make it an attractive agent for limiting the infection spread. The current pilot study provides important preliminary data and may boost larger-scale studies to reach more definitive conclusions. However, for the readers’ benefit and possible optimization of future study designs, we would like to gain more clarity regarding some of the facts presented in the study.

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Regarding Use of Povidone Iodine to Reduce Nasopharyngeal Viral Load in Patients With COVID-19—Reply

Guenezan J, Garcia M, Mimoz O.

Publication date 01-07-2021


Reply We thank Singh and colleagues for their great interest in our study. We agree that the strength of our study was to have performed viral cultures to determine whether the virus was still infectious, and therefore potentially transmissible. A decrease in viral titer at day 1 after inclusion was observed in patients receiving povidone iodine nasopharyngeal decolonization (7%; 95% CI, 43%-95% vs 32%; 95% CI, 10%-65%), but the difference was not significant, as reflected by the overlap in 95% CIs. This finding could be attributed to a lack of power of the study. An imbalance in patient characteristics between groups despite randomization, favored by the small sample size, cannot be excluded either. Patients in the intervention group were younger and had fewer comorbidities, although again the difference was not significant. This may account in part for the greater decline in viral titer at day 1 in the intervention group. Unfortunately, no adjustment of the results for age was feasible owing to the small sample size.

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Associations of Baseline Frailty Status and Age With Outcomes After Vestibular Schwannoma Resection

Dicpinigaitis AJ, Kalakoti P, Schmidt M, et al.

Publication date 01-07-2021


This cross-sectional study evaluates the independent associations of chronological age and frailty (physiological age) with outcomes following vestibular schwannoma resection.

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Epiglottic Mass in an Infant

Tan GX, Helseth P, Roby B.

Publication date 01-07-2021


A 5-month-old boy presents with oropharyngeal bleeding and stridor; laryngoscopy reveals a mucosal soft tissue mass on the epiglottis, and biopsy results show GLUT1-positive endothelial cells. What is your diagnosis?

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Total Thyroidectomy vs Lobectomy for Management of Papillary Thyroid Microcarcinoma

Rosko AJ, Gay BL, Reyes-Gastelum D, et al.

Publication date 01-07-2021


This survey study assessed surgeons’ preference for total thyroidectomy vs lobectomy to treat patients with papillary thyroid cancer.

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Measuring Tracheotomy Risk in Patients With COVID-19

McGrath BA, Naunheim MR, Brenner MJ.

Publication date 01-07-2021


To the Editor Avilés-Jurado and colleagues add another piece to the coronavirus 2019 (COVID-19) jigsaw puzzle with their investigation of 50 patients undergoing surgical tracheostomy for respiratory failure. The study affords insights on timing and reassurances regarding surgeon safety during bedside open tracheostomy in the intensive care unit. A lingering question remains, however, concerning safety of the rest of the health care team during surgery and afterwards.

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Measuring Tracheotomy Risk in Patients With COVID-19—Time to Look Beyond Surgery and Surgeons—Reply

Avilés-Jurado F, Vilaseca I.

Publication date 01-07-2021


In Reply After carefully reading the letter sent by Mc Grath et al, we thank the authors for their comment and compliments regarding our work. We totally agree with them on the importance of considering all professionals in charge of the treatment of the stoma, cannula, and the rehabilitation of the upper airway, at risk beyond the act of tracheostomy.

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Association of Demographic and Geospatial Factors With Treatment Selection for Laryngeal Cancer

Massa ST, Mazul AL, Puram SV, et al.

Publication date 01-07-2021


This cohort study assesses the association between geospatial factors and treatment selection for patients with laryngeal cancer.

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Racial/Ethnic and Sex Representation in US-Based Clinical Trials of Hearing Loss Management in Adults

Pittman CA, Roura R, Price C, et al.

Publication date 01-07-2021


This systematic review assesses sex and racial/ethnic representation in US-based clinical trials of hearing loss management in an adult population.

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Complex Pediatric Otolaryngology Certification

Tunkel DE.

Publication date 01-07-2021


This viewpoint describes the history of pediatric otolaryngology certification efforts and examines some potential ramifications of the proposed certification process.

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Complex Pediatric Otolaryngology Subcertification—Now Is the Time

Messner AH, Rahbar R, Preciado D.

Publication date 01-07-2021


This Viewpoint discusses the need for and goals of the upcoming complex pediatric otolaryngology subcertification.

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Rapid Sequence Induction and Intubation for Patients With Hereditary Hemorrhagic Telangiectasia

Safi C, Troob S, Gudis DA.

Publication date 01-07-2021


This case report describes a middle-aged man with severe recurrent epistaxis refractory to medical therapy who underwent operative ablation of intranasal telangiectasias.

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Efficacy and Safety of Propranolol vs Atenolol in Infants With Problematic Infantile Hemangiomas

Ji Y, Chen S, Yang K, et al.

Publication date 01-07-2021


This randomized clinical trial compares the efficacy and safety of propranolol vs atenolol in Chinese infants with problematic infantile hemangiomas.

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The Need for a Universal Hearing Metric—Is Pure-Tone Average the Answer?

Humes LE, Weinstein BE.

Publication date 01-07-2021


This Viewpoint addresses the recent argument that pure-tone average could fill the need for a universal hearing metric.

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