JAMA Otolaryngology Head and Neck Surgery 2020-12-01

JAMA Otolaryngology–Head & Neck Surgery

Publication date 01-12-2020


Mission Statement: JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions that will enhance the clinician’s understanding of otolaryngologic disorders, benefit the care of our patients, and stimulate research in our field; (2) forecast important advances within otolaryngology–head and neck surgery, particularly as they relate to the prevention, diagnosis, and treatment of disease through clinical and translational research, including that of the human genome and novel imaging techniques; (3) address questions of clinical outcomes and cost-effectiveness that result from clinical intervention, which grow in importance as health care providers are increasingly challenged to provide evidence of enhanced survival and quality of life; (4) provide expert reviews of topics that keep our readers current with true advances and also to provide a valuable educational resource for trainees in the several disciplines that treat patients with diseases of the head and neck; (5) serve as a forum for the concerns of otolaryngologists such as socioeconomic, legal, ethical, and medical issues; (6) provide helpful critiques that enable contributing authors to improve their submissions. We encourage a concise presentation of information and employ an abstract format that efficiently assesses validity and relevance from a clinical perspective. This approach promotes succinct yet complete presentation for our readers and electronic information resources. We believe this approach typifies the commitment of JAMA Otolaryngology–Head & Neck Surgery to providing important information that is easily interpreted by its diverse readership.

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We Survived 2020 With Patient Survivors

Nathan CO, Fakhry C, Moore MG.

Publication date 01-12-2020


This Viewpoint reflects on the experience of the American Head and Neck Society during the COVID-19 pandemic.

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Association of Immigration Status and Chinese and South Asian Ethnicity With Head and Neck Cancer

Noel CW, Sutradhar R, Li Q, et al.

Publication date 01-12-2020


This population-based cohort study examines the independent associations of Chinese and South Asian ethnicity and immigration status with incidence of head and neck cancer.

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Expanding Indications for the Human Papillomavirus Vaccine

Osazuwa-Peters N, Graboyes EM, Khariwala SS.

Publication date 01-12-2020


In the US, the incidence of human papillomavirus (HPV)–related oropharyngeal cancer (OPC) has been growing at an alarming rate for the past 4 decades. In 2011, HPV-related OPC was predicted to surpass cervical cancer in annual incidence in the US by 2020. However, because of the continued decreasing incidence of cervical cancer and the accelerating incidence of OPC, HPV-related OPC actually surpassed cervical cancer to become the most common HPV-related malignancy in the US in 2015. Currently, nearly 19 000 new cases of HPV-related OPC are diagnosed in the US annually. The decrease in cervical cancer incidence is partially attributable to effective screening programs and the early detection of precancerous lesions. Unfortunately, effective screening tests for precancerous HPV-related lesions of the oropharynx are lacking. Therefore, the best opportunity to curb the epidemic of HPV-related OPC is through vaccination against the oncogenic strains of HPV responsible for OPC.

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Omission of Co-First Authorship

Publication date 01-12-2020


In the article titled “Cerebrospinal Fluid Leak After Nasal Swab Testing for Coronavirus Disease 2019” published online on October 1, 2020, there was an omission of co-first authorship in the end matter. Dr Sullivan and Dr Schwalje were both co-first authors. This article was corrected online.

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Oncologic Outcomes Following Transoral Robotic Surgery for HPV-Associated Oropharyngeal Carcinoma

Parhar HS, Shimunov D, Newman JG, et al.

Publication date 01-12-2020


This cohort study examines the outcomes associated with initial transoral robotic surgery in older patients with human papillomavirus–associated oropharyngeal cancer.

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Characteristics and Outcomes of Research Funded by the American Head and Neck Society Foundation

Liu JC, Kupferman M, Kraus D.

Publication date 01-12-2020


This survey study examines the mechanisms and outcomes of grants provided by the American Head and Neck Society for studies on head and neck cancer.

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Error in Results Section

Publication date 01-12-2020


The Original Investigation titled “Effectiveness of Adenotonsillectomy vs Watchful Waiting in Young Children With Mild to Moderate Obstructive Sleep Apnea: A Randomized Clinical Trial,” published in the July 2020 print issue, included an error in the Secondary Outcomes subsection of the Results section. The statement regarding the watchful waiting group that “20 of 26 (76%) had a score greater than 60” should have read “20 of 26 (76%) had a score less than 60.” This has been corrected online.

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Patterns of Multidisciplinary Care of Head and Neck Squamous Cell Carcinoma in Medicare Patients

Hansen CC, Egleston B, Leachman BK, et al.

Publication date 01-12-2020


This cohort study characterizes the patterns of multidisciplinary care use in the treatment of head and neck squamous cell carcinoma among elderly patients in the US.

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Trends in the Implementation of Multidisciplinary Care in Patients With Head and Neck Cancer

Jackson RS, Varvares MA.

Publication date 01-12-2020


Head and neck cancer care is complex and often requires coordination among multiple specialties in a timely fashion to provide optimal outcomes and patient satisfaction. In this issue, Hansen et al evaluate patterns of multidisciplinary care (MDC) in the treatment of head and neck squamous cell carcinoma (HNSCC) among 28 303 elderly patients in the US between 1991 and 2011 using Surveillance, Epidemiology, and End Results–Medicare linked data. The authors define MDC as evaluation by an otolaryngologist, oral surgeon, or head and neck surgeon and radiation oncologist for localized (ie, TMN stage 0-II) cancer and by a medical oncologist for advanced (ie, TMN stage III-IV cancer) before initiating definitive therapy. The aims of the study were to evaluate adherence to MDC and the association between MDC and the time to initiate definitive treatment, which is known to impact survival. The authors found that MDC use continued to increase during the study period, with more than half of patients receiving MDC in 2011. Most elderly patients with localized HNSCC fulfilled the authors’ definition of MDC, but few patients with advanced-stage met the criteria. Patients were more likely to receive MDC if they had localized disease, had a greater overall burden of comorbidities, and were more likely to undergo nonsurgical therapy. The authors suggest that patients with oropharynx or oral cavity tumors are less likely to receive MDC and that consultation with a speech-language pathologist before treatment is rare. The authors also state that there were delays in time to initiate definitive treatment for patients receiving MDC, but there were no delays in time to initiate adjuvant therapy for surgical patients. Last, they were unable to find a difference in oncologic outcomes between those with or without MDC.

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Survival Outcomes in Human Papillomavirus–Associated Nonoropharyngeal Squamous Cell Carcinomas

Sahovaler A, Kim M, Mendez A, et al.

Publication date 01-12-2020


This meta-analysis examines the association between human papillomavirus and survival in patients with oropharyngeal squamous cell carcinoma.

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Cerebrospinal Fluid Leak After Nasal Swab Testing for COVID-19

Sullivan C, Schwalje AT, Jensen M, et al.

Publication date 01-12-2020


This case report describes a woman in her 40s who presented with unilateral rhinorrhea, metallic taste, headache, neck stiffness, and photophobia after completing nasal swab testing for severe acute respiratory syndrome coronavirus 2.

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Effect of Fluorescence Visualization–Guided Surgery on Local Recurrence of Squamous Cell Carcinoma

Durham J, Brasher P, Anderson DW, et al.

Publication date 01-12-2020


This randomized clinical trial compares the effect of fluorescence visualization– vs white light–guided surgery on local recurrence rates in patients with oral squamous cell carcinoma.

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Better Visualization of Oral Cancer Margins

Pagedar N.

Publication date 01-12-2020


Homer’s epic poem The Odyssey relates the circuitous path taken by its protagonist as the Achaeans disperse, having sacked the city of Troy. Strikingly clever but beset by misfortune, natural obstacles, malevolent gods bearing grudges, and his own hubris, Odysseus struggles to find his way to Ithaca.

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Error in Author Name

Publication date 01-12-2020


The Original Investigation titled “Association of Immunosuppression With Outcomes of Patients With Cutaneous Squamous Cell Carcinoma of the Head and Neck,” published online December 5, 2019, was corrected to add a missing initial to author Christopher M. K. L. Yao’s name in the byline. This article was corrected online.

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Error in Affiliations

Publication date 01-12-2020


The Original Investigation titled “Assessment of Factors Associated With Internal Carotid Injury in Expanded Endoscopic Endonasal Skull Base Surgery,” published online February 27, 2020, was corrected to fix the affiliation for author Christos Georgalas, which was incorrectly published as the Department of Otorhinolaryngology–Head & Neck Surgery, Hygeia Hospital, Athens, Greece; the correct affiliation is Medical School, University of Nicosia, Nicosia, Cyprus. This article was corrected online.

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Hyperprogression of a Sinonasal Squamous Cell Carcinoma Following PD-1 Checkpoint Blockade

Izreig S, Alzahrani F, Earles J, et al.

Publication date 01-12-2020


This case report describes man in his 60s who presented with a maxillary sinus squamous cell carcinoma and experienced hyperprogression following treatment with pembrolizumab.

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Outcomes of a Telephone-Based Questionnaire to Follow Up Patients Treated for Oral Cancer

Malik A, Nair S, Sonawane K, et al.

Publication date 01-12-2020


This diagnostic study uses data from patients treated for oral cancer at a tertiary care cancer center in India to investigate the clinical value of a telephone-based questionnaire in detecting cancer recurrence during follow-up evaluation.

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Response to Electrochemotherapy in a Patient With Advanced Oropharyngeal Squamous Cell Carcinoma

Pichi B, Petruzzi G, Zocchi J, et al.

Publication date 01-12-2020


This case report describes a 61-year-old man who presented with dysphagia, drooling, and an ulcerated mass in the right oropharyngeal region.

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Adjuvant Chemoradiation for Pathologic N2a Human Papillomavirus–Negative Head and Neck Cancer

Yan F, Li H, Kaczmar JM, et al.

Publication date 01-12-2020


This cohort study uses data from the National Cancer Database to assess whether adding chemotherapy to adjuvant radiation therapy is associated with improved survival among patients with human papillomavirus–negative head and neck squamous cell carcinoma with extranodal extension from a single lymph node smaller than 3 cm.

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